Condition Notes ITP due to antibodies made after viral infection.mucocutaneous bleeding (epistaxis, hematuria, ecchymosis, petechiae) ↓PLT↑BT (normal PT & PTT)normal/ slightly ↑ size observe only if mild (cutaneous bleeds, PLT ≥30,000)Steroids/IVG/anti-D if severe (bleeding or PLT<30,000)Test for HCV & HIV TTP hereditary/ acquiredAntibody against ADAMTS13 → uncleared vWF multimers → PLT trapping & activationfever, neuro sx, renal failure ↓PLT with hemolysis (↑LDH, ↓haptoglobin, ↓RBC, schistocytes)↑BT (normal PT & PTT) plasma exchange/ steroids/ rituximabreplenishes ADAMTS13 & removes antibodies HIT-1 heparin activates PLT directly → ↓PLT count within the first 2 days of use. Then PLT normalizes. Milder than HIT-2 HIT-2 auto-immune: antibodies against PLT factor 4 (PF4) complex with heparin. Seen…