Biostatistics

Types of Research Studies

Experimental studies:
Randomized control trial (RCT)can determine efficacy of treatment
random
Non-random study
Observational studies:
Cohort studyrisk factors/ outcomes
longitudinal
incidence
Cross-sectional studyprevalence
snapshot
assoc. between risk factors & disease
used to generate hypothesis (Ho) & sometimes to test Ho
Case-control studycases (disease positive) compared to controls (disease negative)
looks at odds of exposure
Case report seriesone person or small group of people
detailed info
used to generate Ho
Reviews:
Meta-analysisdata from multiple studies combined and analyzed
Systematic reviews
Experts:
Expert opinions & panels

Grades of evidence in research studies

Meta-analysis and systemic reviews are the research studies with the best evidence, grade 1 evidence. Randomized control trials follow closely, then the observational studies with cohort studies coming in first. When looking at research studies to evaluate the quality of evidence it is important to keep this in mind.