Blood Transfusion Reactions
| Type | Tx | |
| Anaphylactic | Immediate IgA deficiency Angioedema | Stop transfusion IM Epi +/- Bronchodilators/ antihistamine |
| Acute hemorrhagic | <1h ABO incompatibility +Coombs flank pain, fever, hemoglobinuria, DIC | Stop transfusion IVF, supportive care |
| Febrile non-hemolytic | 1-6h fever, chills | Stop transfusion Antipyretics Prevention: filter out WBC (leuko-reduction) |
| Urticarial | 2-3h IgE | Stop transfusion Antihistamine (eg diphenhydramine) |
| Transfusion-related acute lung injury (TRALI) | <6h donor anti-leukocyte antibodies Resp. distress, pulmonary edema | Stop transfusion Supportive care (may need ventilator) 50% die, rest better in 1-2 days |
| Delayed hemolytic | days-weeks later Anamesic antibody +Coombs, +Ab screen asymptomatic | |
| Graft vs Host | <weeks Donor T lymphocytes Pancytopenia, GI Sx, rash, fever | Steroids |
| Bacterial Sepsis | min-hours fever, shock, DIC | |
